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Concepts in Genetic Medicine by Boro Dropulic, Barrie Carter

By Boro Dropulic, Barrie Carter

This booklet grants a suite of geared up and succinct studies within the box of healing genetic medication offered by means of a gently chosen workforce of most sensible specialists. each one bankruptcy makes a speciality of a unmarried, present subject and explains matters within the improvement of genetic remedies, severe demanding situations and methods for enforcing them, and destiny instructions in study and translational functions. The booklet is complemented with uniformly designed illustrations and a supplementary website with a PowerPoint presentation for educators.

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Amendola M, Venneri MA, Biffi A, Vigna E, Naldini L. Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat Biotechnol . 2005;23:108–116. 61. Szymczak AL, Workman CJ, Wang Y, et al. Correction of multi-gene deficiency in vivo using a single ‘self-cleaving’ 2A peptide-based retroviral vector. Nat Biotechnol . 2004;22:589–594. 62. Chinnasamy D, Milsom MD, Shaffer J, et al. Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI.

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28. Takahashi K, Luo T, Saishin Y, et al. Sustained transduction of ocular cells with a bovine immunodeficiency viral vector. Hum Gene Ther. 2002;13:1305–1316. 29. Ikeda Y, Ylinen LMJ, Kahar-Bador M, Towers GJ. Influence of gag on human immunodeficiency virus type 1 species-specific tropism. J Virol . 2004;78: 11816–11822. 30. Kootstra NA, Munk C, Tonnu N, Landau NR, Verma IM. Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells. Proc Natl Acad Sci U S A.

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