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Colposcopy in Diagnosis and Treatment of Preneoplastic by H. E. Stegner (auth.), Professor Dr. med. Hans-E. Stegner,

By H. E. Stegner (auth.), Professor Dr. med. Hans-E. Stegner, Professor Dr. med. Malcolm Coppleson (eds.)

This e-book provides fresh advancements within the epidemiology and normal heritage of the early levels of melanoma of the uterine cervix, vulva and vagina, and on major advances in therapy methods. Electrodiathermy, cryosurgery, and extra lately carbon dioxide laser have confirmed to be applicable instruments to spoil the bizarre epithelia with out mutilating the organs affected. an important unmarried issue taken with good fortune of those innovations is a meticulous pre-treatment overview of the sufferer in accordance with skilful colposcopic exam to figure out the complete quantity of any lesion. this may basically be performed through a doctor completely skilled in colposcopic analysis and with entire realizing of the histogenesis of intraepithelial neoplasia. within the current ebook the necessities for prognosis and therapy are laid down via specialists from around the world. The contributions should be of significant price to people who take care of early detection and administration of gynecological melanoma.

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Plasmids were kindly provided by Professor H. zur Hausen, Deutsches Krebsforschungszentrum, Heidelberg, FRG. References Almeida JD (1980) Practical aspects of diagnostic electron microscopy. Yale J Bioi Med 53:5-18 Brigati DJ, Myerson D, Leary JJ, Spalholz B, Travis SZ, Fong CKY, Hsiung GD, Ward DC (1983) Detection of viral genomes in cultured cells and paraffinembedded tissue sections using biotin-labeled hybridization probes. Virology 126:32-50 Chernesky MA, Mahony JB (1984) Detection of viral antigens, particles and early antibodies in diagnosis.

5, 100 mMNaCL, 5 mMMgCh for 15 min in the dark. In order to inhibit endogenous alkaline phosphatase activity, 1 fil/m1 1evamiso1e (Sigma) is added to the substrate solution. 5, 1 mM EDTA, and the sections are photographed without and with counterstaining. Results and Discussion Papillomaviruses have long been known to be the etiological agent of benign mucocutaneous papillomas. For cervical precancer and cancer, the present epidemiological and molecular-biological data support the assumption that papillomaviruses are not simply passengers in tumor cells (Pfister 1986).

Ciba Found Symp 120:86-103 Myerson D, Hackman RC, Myerson JD (1984) Diagnosis of cytomegaloviral pneumonia by in situ hybridization. J Infect Dis 150:272-277 Orth G (1986) Epidermodysplasia verruciformis: a model for understanding the oncogenicity of human papillomaviruses. In: Papillomaviruses. Ciba Found Symp 120:157-174 Pfister H (1986) Papillomviren und Tumorkrankheiten des Menschen. Ber Path 103 :177-186 Reid R, Crum CP, Herschman BR, Fu YS, Braun L, Shah KV, Agronow SJ, Stanhope CR (1984) Genital warts and cervical cancer.

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