Most searched books


Chemistry and Application of H-Phosphonates by Kolio D. Troev

By Kolio D. Troev

Chemistry and alertness of H-Phosphonates is a superb resource for these making plans the synthesis of recent phosphorus-containing compounds and specifically derivatives containing a phosphonate, phosphoramide or phosphonic acid diester workforce. the wealthy chemistry, cost-effective and simple availability of diesters of H-phosphonic acid makes them a superb selection as synthone in a couple of virtually very important reactions.Phosphonic acid esters are intermediates within the synthesis of significant periods of compounds resembling alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of every of those compound sessions is reviewed in detail.Alpha-Aminophosphonic acids are a huge classification of biologically energetic compounds, that have acquired an expanding volume of consciousness simply because they're thought of to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic brokers are good documented. Alpha-Hydroxyalkanephosphonates are compounds of vital organic and medicinal purposes. Dialkyl epoxyalkylphosphonates are of curiosity as a result of their use as intermediates within the synthesis of bioactive ingredients, and as modifiers of typical and artificial polymers. Bisphosphonates are medications which were universal in several bone illnesses, and feature lately been used effectively opposed to many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of gear. Nucleoside H-phosphonates appear to be the main beautiful applicants as beginning fabrics within the chemical synthesis of DNA and RNA fragments. The 5'-hydrogen phosphonate-3'-azido-2',3'-dideoxythimidine is without doubt one of the most important anti-HIV prodrug, that's at present in scientific trials.

Show description

Read or Download Chemistry and Application of H-Phosphonates PDF

Similar inorganic books

Inorganic Syntheses, Volume 2

The volumes during this carrying on with sequence offer a compilation of present thoughts and ideas in inorganic artificial chemistry. contains inorganic polymer syntheses and training of significant inorganic solids, syntheses utilized in the advance of pharmacologically lively inorganic compounds, small-molecule coordination complexes, and comparable compounds.

Including Bioinorganic Studies

Advances in Inorganic Chemistry provides well timed and informative summaries of the present growth in a number of topic components inside inorganic chemistry starting from bio-inorganic to sturdy kingdom reviews. Thisacclaimed serial positive factors stories written via specialists within the region and is an essential connection with complicated researchers.

Functional metallosupramolecular materials

There's nice curiosity in metallosupramolecular fabrics as a result of their use in magnetic, photonic and digital fabrics. sensible Metallosupramolecular fabrics makes a speciality of the purposes of those fabrics masking the chemistry underlying the synthesis of a number of ligands to coordinate a variety of steel ions and the new release of 2nd and 3D fabrics in accordance with those constructs.

Inorganic Chemistry

Учебник по неорганической химии. Shriver and Atkins Inorganic Chemistry 5th version represents an essential component of a scholars chemistry schooling. With an identical extensive assurance as its predecessors - making it the suitable spouse at some point of an undergraduate measure programme - the 5th variation extends from the foundational strategies of inorganic chemistry to the vanguard of up to date study.

Additional resources for Chemistry and Application of H-Phosphonates

Sample text

In this metallo-phosphonate intermediate, the phosphorus atom plays the role of a nucleophile.

Qxd 6/14/2006 4:16 PM Page 52 52 3. Reactivity of H-Phosphonates ozone layer [121]. Chlorofluorohydrocarbons have been proposed as refrigerant substitutes for chlorofluorocarbons [122]. The latter molecules are considered environmentally less harmful because they contain a carbon–hydrogen bond that can be cleaved by chemical reactions at lower altitudes, thereby preventing the compounds from reaching the stratosphere. The Atherton–Todd reaction of halocarbons with dialkyl H-phosphonates is one potentially useful reaction that can be used to carry out such transformation under homogeneous conditions [123].

In this compound, mobile protons are not present in the ring; H2C H2C O O HC O O OH P P H2C H O H the form with P–OH bond is not observed [56]. Diphenyl H-phosphonate reacts with aliphatic saturated mercaptans and unsaturated mercaptans with the formation of thio and dithio H-phosphonates [59]. O (PhO)2P(O)H PhO- P- SCH2CH3 + CH3CH2SH - PhOH H (PhO)2P(O)H + H2C = CH - CH2SH O PhO- P- SCH2CH = CH2 H O CH2 =CH -CH2S- P- SCH2CH = CH2 H H-phosphonate diesters having double or triple bonds in their alkoxy chains can be synthesized by transesterification of the lower homologues with unsaturated alcohols [60–62].

Download PDF sample

Rated 4.52 of 5 – based on 21 votes

Comments are closed.