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Biological Effects of Alcohol by Henri Begleiter (eds.)

By Henri Begleiter (eds.)

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Mals. Although an acute dose of ethanol (3 g/kg) stimulated dopamine synthesis, as measured eight hours after treatment, there was ho difference in DOPA accumulation between ethanol-withdrawn and control animals at any time tested after withdrawal from chronic ethanol treatment (78; Fig. I), How_ever, stimulation of dopamine synthesis by low doses of pimozide was significantly reduced in animals which had been wjthdrawll from ethanol for eight hours (78). gnificant at 24 hours after withdrawal <78; Fig.

Histamine-sensitive adenyl ate cyclase in mammal ian brain. Nature 260: 163-165, 1976. 55. B. A. Dopamine-sensitive adenylate cyclase from the rat caudate nucleus: regulation by guanyl nucleotides and the interaction of magnesium and magnesium ATP. J. Neurochem. 30: 1163-1172, 1978. 56. W. and Greengard, P. Characterization of dopamine-sensitive adenylate cyclase in the rat caudate nucleus. J. Neurochem. 25: 143-149, 1975. 57. Pfeiffer, T. GTP-binding proteins in membranes and the control of adenylate cyclase activity.

40: 99-113, 1977. 77. , Guidotti, A. and Costa, E. The regulation of the kinetic peak of strial tyrosine hydroxylase and the role of post-synaptic dopamine receptors. Brain Res. 92: 516-521,1975. 78. Tabakoff, B. L. Alterations in receptors controll ing dopamine synthesis after chronic ethanol ingestion. J. , in press. 79... , Carlsson, A. and Lindqvist, M. A method for the determination of 3,4-dihydroxyphenylalanine (DOPA) in brain. -S. Arch Pharmacol. 274: 273-280,1972. 80. H. H. and Greengard, P.

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