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Adenosine Receptors - Therapeutic Asps. for Inflamm., Immune by G. Hasko

By G. Hasko

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43, 2227, 2000. 52. G. , Allosteric modulation of A3 adenosine receptors by a series of 3-(2pyridinyl)isoquinoline derivatives, Mol. , 60, 1057, 2001. 53. E. , Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists, J. Med. , 44, 749, 2001. 54. Y. , Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists, Bioorg. Med. , 12, 613, 2004. 55. J. , New highly potent and selective adenosine A3 receptor antagonists, Curr.

31 We deleted exon 3, Koszalka et al. deleted exon 2, and Castrop et al. deleted both exons 2 and 3. As expected, all three strains of CD73 gene-targeted mice are markedly deficient in ecto-5′-nucleotidase enzyme activity in every tissue examined. Heterozygous mice have intermediate levels of enzyme activity, consistent with a gene dosage effect. Cell-surface-expressed CD73 as assessed by immunofluorescence is also undetectable on the lymphoid cells of our mice. Cd73-deficient mice appear normal and are healthy when maintained in conventional housing.

973, 2005. 30. A. , Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A3 receptor with selectively enhanced affinity for aminemodified nucleosides, J. Med. , 44, 4125, 2001. 31. K. , Modeling the adenosine receptors: comparison of binding domains of A2A agonist and antagonist, J. Med. , 46, 4847, 2003. 32. A. , Chem. , 12, 237, 2005. 33. Moro, S. , Autocorrelation of molecular electrostatic potential surface properties combined with partial least squares analysis as new strategy for the prediction of the activity of human A3 adenosine receptor antagonists, J.

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